Don’t take a pain reliever before your COVID-19 vaccine. As for whether you should try to preempt your vaccine side effects with a pain reliever, Cennimo advises against it. “In the COVID-19 Our cohort of gouty arthritis patients on diclofenac demonstrated 5.29 times higher risk to have UGIB compared to those not on diclofenac. A meta-analysis showed that a positive relationship between diclofenac dose and with increased risk for UGIB or cardiovascular event compared with other NSAIDs (Odom et al., 2014). To the best of our propionic acids (naproxen and ibuprofen) enolic acids (meloxicam and piroxicam) acetic acids (diclofenac and indomethacin) naphthylalanine (nabumetone) selective COX-2 inhibitors (celecoxib When using Ibuprofen, the following side effects may also occur: headache, twisting, fatigue, tightness, rash and itching. The list of side effects with Diclofenac is even larger. This can be expanded with, among other things, hepatitis, depression, impaired renal function and ovarian cancer. Patients should not take two NSAIDs together. Doing so may increase the risk of significant side effects, such as stomach upset and bleeding. IMPORTANT NOTE: In some cases physicians will instruct patients to take 81 mg Aspirin in those cases aspirin and diclofenac are safe. Doses > 81 mg of Aspirin may not be safe. Aleve (Naproxen Sodium) A meta-analysis compared the cardiovascular safety of naproxen, ibuprofen, diclofenac, and celecoxib. 7 It included 31 RCTs (N = 120,000 patients) that had more than 100 patient-years of follow-up Nu8UVf.